Tyck till om SwePub Sök
här!
Search: WFRF:(Almgren P.)
> (2005-2009)
> Tuomi T.
> (2007) >
Association testing...
Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes
-
Florez, J. C. (author)
-
- Sjögren, Marketa (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - hypertoni,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Cardiovascular Research - Hypertension
-
Agapakis, C. M. (author)
-
show more...
-
Burtt, N. P. (author)
-
- Almgren, Peter (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
-
- Lindblad, Ulf (author)
- Lund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Samhällsmedicin,Family Medicine and Community Medicine,Lund University Research Groups,Community Medicine
-
- Berglund, Göran (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
-
Tuomi, T. (author)
-
Gaudet, D. (author)
-
Daly, M. J. (author)
-
Ardlie, K. G. (author)
-
Hirschhorn, J. N. (author)
-
Altshuler, D. (author)
-
- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
-
show less...
-
(creator_code:org_t)
- 2007-04-19
- 2007
- English.
-
In: Diabetologia. - : Springer Science and Business Media LLC. - 1432-0428 .- 0012-186X. ; 50:6, s. 1209-1217
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://link.springe...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Aims/hypothesis Activation of the insulin receptor substrate-1 (IRS1) is a key initial step in the insulin signalling pathway. Despite several reports of association of the G972R polymorphism in its gene IRS1 with type 2 diabetes, we and others have not observed this association in well-powered samples. However, other nearby variants might account for the putative association signal. Subjects and methods We characterised the haplotype map of IRS1 and selected 20 markers designed to capture common variations in the region. We genotyped this comprehensive set of markers in several family-based and case-control samples of European descent totalling 12,129 subjects. Results In an initial sample of 2,235 North American and Polish case-control pairs, the minor allele of the rs934167 polymorphism showed nominal evidence of association with type 2 diabetes (odds ratio [OR] 1.25, 95% CI 1.03-1.51, p=0.03). This association showed a trend in the same direction in 7,659 Scandinavian samples (OR 1.16, 95% CI 0.96-1.39, p=0.059). The combined OR was 1.20 (p=0.008), but statistical correction for the number of variants examined yielded a p value of 0.086. We detected no differences across rs934167 genotypes in insulin-related quantitative traits. Conclusion/interpretation Our data do not support an association of common variants in IRS1 with type 2 diabetes in populations of European descent.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- SNP
- type 2 diabetes
- common variants
- insulin resistance
- IRS1
- disequilibrium
- linkage
- single nucleotide polymorphism
- genetic association
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Florez, J. C.
-
Sjögren, Marketa
-
Agapakis, C. M.
-
Burtt, N. P.
-
Almgren, Peter
-
Lindblad, Ulf
-
show more...
-
Berglund, Göran
-
Tuomi, T.
-
Gaudet, D.
-
Daly, M. J.
-
Ardlie, K. G.
-
Hirschhorn, J. N ...
-
Altshuler, D.
-
Groop, Leif
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
Diabetologia
- By the university
-
Lund University